The mature active peptide is cleaved and released after Arg298 by furin-like proteases
The mature active peptide is cleaved and released after Arg298 by furin-like proteases. In the next family where CL/P was the just phenotype, a mutation in (encoding the GDF11 antagonist, Follistatin) was discovered that is forecasted to bring about a p.(Cys56Tyr) substitution in your community that binds GDF11. Functional assays confirmed a substantial influence of…