There is strong experimental evidence, obtained using both pharmacological inhibitors and genetically modified animals, that NO production by the microvascular endothelium plays a critical role in NVC responses and that cerebromicrovascular endothelial dysfunction significantly contributes to age-related neurovascular dysfunction (Toth et al. in aging, similar to the recently demonstrated protective effects of treatment with the…

Read More “There is strong experimental evidence, obtained using both pharmacological inhibitors and genetically modified animals, that NO production by the microvascular endothelium plays a critical role in NVC responses and that cerebromicrovascular endothelial dysfunction significantly contributes to age-related neurovascular dysfunction (Toth et al” »