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Discovery and Biological Characterization of Potent MEK inhibitors in melanoma

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Subsequent treatment of compound 34 with sodium hydride, followed by reaction with propargyl bromide, gave the desired acetylene 14

Posted on October 7, 2021 By scienzaunder18

Subsequent treatment of compound 34 with sodium hydride, followed by reaction with propargyl bromide, gave the desired acetylene 14. The incorporation of the methyl group allowed preparation of a POM-prodrug, which displayed a 10-fold increase in cellular activity compared to the corresponding salt. These studies form the basis for future preclinical studies investigating the anti-myeloma…

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