Along the same lines, preclinical work with BMS-936564/MDX-1338, a therapeutic anti-human CXCR4 monoclonal antibody, revealed that this CXCR4 antagonist also induced downstream signalling (Kuhne2013)
Along the same lines, preclinical work with BMS-936564/MDX-1338, a therapeutic anti-human CXCR4 monoclonal antibody, revealed that this CXCR4 antagonist also induced downstream signalling (Kuhne2013). of CXCR4 antagonists is usually primarily due to CXCR4 inhibition, rather than agonistic activity, and corroborate that CXCR4 is an important target to overcome stroma-mediated drug resistance in B-ALL. 2014), and…