[PubMed] [Google Scholar] 10. that accumulates Pax1 at focus on promoters but does not stimulate RNA-Pol-II elongation and following transcription of focus on genes. Therefore, the anti-proliferative activity of IRF1 is normally dropped in cell lines expressing T181A mutant. Further, cell lines with dysfunctional Fbxw7 are much less delicate to IRF1 overexpression, recommending a significant…

Read More “[PubMed] [Google Scholar] 10” »

Given the data presented here, loss of DUSP6 may provide a novel mechanism by which losses of DUSP6 during the pancreatic cancer progression may contribute to accumulation of DNA breaks and lead to genomic instability. As a general principle, DDR causes a delay in cell cycle progression to permit DNA restoration, or if the damage…

Read More “Given the data presented here, loss of DUSP6 may provide a novel mechanism by which losses of DUSP6 during the pancreatic cancer progression may contribute to accumulation of DNA breaks and lead to genomic instability” »