To specifically analyze malignancy cells, we used areas of colocalization of puromycin with cytokeratin, a malignancy cell-specific marker
To specifically analyze malignancy cells, we used areas of colocalization of puromycin with cytokeratin, a malignancy cell-specific marker. branched chain ketoacid (BCKA)-reliance in PDAC cells in stroma-rich tumors. We statement that cancer-induced stromal reprogramming fuels this BCKA demand. The TGF-/SMAD5 axis directly focuses on BCAT1 in CAFs and dictates internalization of the extracellular matrix from…