We display here that fumarate-mediated succination of ACO2 impairs its enzymatic activity inside a dose-dependent manner and that Fh1KO cells exhibit reduced aconitase activity. Our data provide evidence that succination, resulting from FH deficiency, focuses on and potentially alters the function of multiple proteins and may contribute?to the dysregulated metabolism observed in HLRCC. Abstract Graphical…

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-tubulin was used as a loading control. DAPI (blue) and antibodies against Flag (red) and -tubulin (green). Control denotes expression of an irrelevant Flag-tagged protein. NIHMS6343-supplement-3.pdf (7.0M) GUID:?605D16DC-EE94-4C21-910F-42915DB736A0 4: Figure S4 A ~1.5 fold overexpression of Flag-Cep76 is sufficient to rescue centriole amplification induced by loss of Cep76 or HU treatment. (A) U2OS cells were…

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Hyperkalemia is another common side effect. weeks or months later [7]. The cough is predominantly seen in females and non-smokers [4,8C12]. However, the pathogenesis of ACE-I-induced cough remains controversial. The underlying mechanisms of the ACE-I-induced cough are multifactorial. Angiotensin-Converting Enzyme Inhibition Mechanism Angiotensin-converting enzyme (ACE) inhibition mechanism is a very important development in hypertension treatment….

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