We hypothesized that methylation of recently synthesized DNA in proliferating cells could be altered by oxidants that focus on DNA methyltransferase activity or deplete its substrate, the methyl donor SAM
We hypothesized that methylation of recently synthesized DNA in proliferating cells could be altered by oxidants that focus on DNA methyltransferase activity or deplete its substrate, the methyl donor SAM. the epigenome of neighboring cells. methylation, which is mediated by DNMT3 isoforms during embryo differentiation and development. DNMTs work with a nucleophilic cysteine residue to…